Bugs and Humans don’t like Jet Lag:
by Dr. Kadish
In a recent publication mice and 2 folks were checked for changes in their bacterial content of their guts. Not unlike how our head tells us that the time shift is less than something we appreciate, the same holds true for the bugs.
Interestingly this has a very significant impact on those who fly frequently. It took 2 weeks for the bacteria to return to normal. The problem….if you fly frequently you don’t allow for the normal return of the optimal gut mix and you set yourself up of both diabetes and obesity.
If your reading the newspapers or science magazines during the last number of months the amount of new research on the subject of your gut bugs has gone viral. To distill the essence, we are totally getting tons of input from our gut bacterial and how we treat them in terms of nutrition, rhythm, and our daily exposures.
At the Center we work with this current level of knowledge and take the time to make certain that your gut bugs are in concert with your health desires.
Time for a check up including your gut bugs…… call us at 541.773.3191
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Christoph A. Thaiss,David Zeevi,Maayan Levy,Gili Zilberman-Schapira, Jotham Suez,Anouk C. Tengeler, Lior Abramson, Meirav N. Katz, Tal Korem, Niv Zmora, Yael Kuperman, Inbal Biton, Shlomit Gilad, Alon Harmelin, Hagit Shapiro, Zamir Halpern, Eran Segal, Eran Elinav
- •Intestinal microbiota exhibit diurnal oscillations in composition and function
- •Feeding rhythms direct microbiota oscillations
- •Chronic jet lag is associated with loss of microbiota rhythms and dysbiosis
- •Jet-lag-associated dysbiosis in mice and humans promotes metabolic imbalances
All domains of life feature diverse molecular clock machineries that synchronize physiological processes to diurnal environmental fluctuations. However, no mechanisms are known to cross-regulate prokaryotic and eukaryotic circadian rhythms in multikingdom ecosystems. Here, we show that the intestinal microbiota, in both mice and humans, exhibits diurnal oscillations that are influenced by feeding rhythms, leading to time-specific compositional and functional profiles over the course of a day. Ablation of host molecular clock components or induction of jet lag leads to aberrant microbiota diurnal fluctuations and dysbiosis, driven by impaired feeding rhythmicity. Consequently, jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation. Together, these findings provide evidence of coordinated metaorganism diurnal rhythmicity and offer a microbiome-dependent mechanism for common metabolic disturbances in humans with aberrant circadian rhythms, such as those documented in shift workers and frequent flyers.
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