Natural Medicine works for helping conception in endometriosis eggs
By Dr. Alan Kadish NMD
In some new findings, the eggs of those suffering with endometriosis have been shown to have high levels of oxidation. There appears to be a direct relationship to the level of oxidation and egg fertility. The high levels of oxidation, think rusting caused the eggs to not mature.
Two natural product were used in this in-vitro (out of the body testing) study, using melatonin, and resveratrol. Both of these natural agents have been shown to be highly active and non-toxic in adults. The melatonin has been an over the counter hormone available for 20+ years and used as a sleeping aid by many. It also has been scientifically shown to act as an antioxidant when used.
Resveratrol is derived from either grape skins or berries and has a long history of use for it’s antioxidant and antimutagenic properties. For those of you considering wine as the source….not so fast. It’s not contained in any notable quantity in white wines and limited relative to the therapeutic levels in reds. This means it has been shown to be active in a number of disorders including, cancer, diabetes, cognition, and cardiovascular disease.
The results of the combined use of these supplements was that the eggs retained their function, unlike the failures that had occurred without the supplement additions. Is it a bit too early to conclude that this is a panacea for those with endometriosis and suffering from infertility ? I don’t think so as the effects will be a positive impact to the endometrial disorder.
The use of these agents has shown us, in clinic, substantial results that suggest it’s use is both warranted and effective.
Have questions and want to know how much to take, as well as which brands ? Call us at the Center of Health and let’s start a dialogue to optimize your health. 541.773.3191
New hope given to women struggling to conceive
University of Southampton News, 12/05/2016
In a collaborative study between researchers at the University of Southampton and Princess Anne Hospital’s Complete Fertility Centre, it was found that egg quality is severely compromised in endometriosis.
Published in the journal Scientific Reports, the study found that the ability of the egg to mature was blocked by endometriosis, and furthermore that eggs could suffer serious damage by exposure to follicular fluid from women with endometriosis.
Dr Simon Lane, Research Fellow at the University of Southampton who led the study said: “We believe these results could have clinical implications for many women struggling to fall pregnant. We found that fluid from the follicles of patients with endometriosis was found to block egg maturation by generating free–radical chemicals called Reactive Oxygen Species (ROS) in the egg, which damaged their DNA. This damage caused the egg not to mature, and hence it could not be fertilized. More research is now needed to investigate whether the damage caused by endometriosis is treatable or preventable.”
The study involved taking immature mouse eggs and incubating them in follicular fluid taken from women who have endometriosis, in vitro. The researchers examined the amounts of ROS that were generated and the ability of the egg to mature. They found the follicular fluid from women with endometriosis resulted in higher amounts of ROS.
The research team believes that the effects of endometriosis on maturing eggs could be prevented by antioxidants. During the study the team analysed the effects of two antioxidants. Resveratrol, which is found in the skins of grapes and berries and Melatonin, a compound released during sleep, were added to the fluid and were shown to reverse the negative effects; ROS levels decreased and more eggs were able to mature.
Ying Cheong, Clinical Director of the Complete Fertility Clinic and Professor of Reproductive Medicine at the University of Southampton, added: “Endometriosis is strongly associated with infertility and up to 50 per cent of women who require infertility treatment have it. Struggling to have a baby can be terribly upsetting for a couple, so this new research gives some hope to people. It is very encouraging to see the possibility of the damage being prevented by antioxidants but more work is needed before we can put our results into practice.”
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