Autism and Toxins:

by Dr. Alan Kadish

In my clinical practice I have seen repeatedly the elevated levels of various toxins in my ASD patients. This review article describing how environmental toxins can impact a specific set of signals makes so much sense based on the chemistry that they found affected.

The effects of omega 3 oils (good guys) as one means of modulating the prostaglandin e2’s (in excess, bad guys) should be an obvious intervention with minimal cost or side effects. We know since the 1970’s that you can change the PGE2 levels with simple fish oil increases in both the diet or by using supplements.  

The suggestion that women in all stages of planning through breast feeding use a omega 3 supplement, not only for fetal brain development but also to change the level of PGE2’s might become a recognized therapy to minimize the incidence of ASD.

Obviously this is but one pathway that is disrupted during fetal development, but it gives us another insight into how to potentially decrease the risk and/or incidence of ASD, naturally and with a high safety index.

Quality of the product used along with the correct ratio of DHA to EPA is another important consideration, based on where you are in the planning, pregnancy or breast feeding phase. We only use 3rd party assayed products that have minimal manipulation to the oils and not the prescription version.

Curious to learn more ? Call the Center at 541.773.3191 

 

Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

Christine T. Wong, Joshua Wais and Dorota A. Crawford
School of Kinesiology and Health Science, York University, Toronto, ON, Canada M3J 1P3  Neuroscience Graduate Diploma Program, York University, Toronto, ON, Canada M3J 1P3  Department of Biology, York University, Toronto, ON, Canada M3J 1P3

Keywords: autism, blood brain barrier, chemicals, lipids, prostaglandin Edited by Sophie Molholm

Received 29 April 2015, revised 21 July 2015, accepted 23 July 2015

Abstract

The prevalence of autism spectrum disorders (ASDs) has been on the rise over recent years. The presence of diverse subsets of candidate genes in each individual with an ASD and the vast variability of phenotypical differences suggest that the interference of an exogenous environmental component may greatly contribute to the development of ASDs. The lipid mediator prostaglandin E2 (PGE2) is released from phospholipids of cell membranes, and is important in brain development and function; PGE2 is involved in differentiation, synaptic plasticity and calcium regulation. The previous review already described extrinsic factors, including deficient dietary supplementation, and exposure to oxidative stress, infections and inflammation that can disrupt signaling of the PGE2 pathway and contribute to ASDs. In this review, the structure and establishment of two key protective barriers for the brain during early development are described: the blood–brain barrier; and the placental barrier. Then, the first comprehensive summary of other environmental factors, such as exposure to chemicals in air pollution, pesticides and consumer products, which can also disturb PGE2 signaling and increase the risk for developing ASDs is provided. Also, how these exogenous agents are capable of crossing the protective barriers of the brain during critical developmental periods when barrier components are still being formed is described. This review underlines the importance of avoiding or limiting exposure to these factors during vulnerable periods in development.

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Dr. Kadish is an unusual physician often referred to as a "doctor detective". His expertise is the evaluation and treatment of complex disorders, typically after other physicians have been stumped, is renowned. He provides care for all family members and has additional training in autistic spectrum disorders and chronic complex diseases.