ALS and toxins causation ?

Br Dr. Alan Kadish NMD

My experience with ALS patients goes back to the 1990’s when I had the opportunity to work with a very motivated gal who had 4 separate neurologists diagnose her. She was unwilling to give up her life and decided to go full bore into detox from amalgam removals to IV infusions and chelation with sauna treatment. 

Twenty years latter she was still doing well with only a moderate amount of muscle loss but still at the gym and moving forward with her life with only very minimal issues. This was one of those unusual patients willing and able to do anything to remain on the planet.

The current review of ALS confirmed patients and their blood characteristics of having notable levels of pesticides, fire retardants and pcb’s should be another hard kick in the pants to go as non-toxic in our lifestyle choices as possible.

It take some time, thought and often the help of a professional to get a handle on where your exposures lie and how to address them effectively.

It’s now both easy and cost effective to get the correct tests and know if your exposures to these chemicals are present in your system.

Considering your history, have you been in or around a farming community, in the military, used or are currently using pesticides in your garden ? Even if not, wind and water may be contributing factors. Are you sitting on old (pre 2015) furniture made with fireproofing agents ?

At the Center of Health we have been providing in home evaluation services as well as the needed medical interventions to work towards prevention. Call us at : 541.773.3191 

 

How Lifestyle Choices May Affect ALS Risk

David Perlmutter MD

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is almost uniformly fatal and is only increasing in incidence. While no one has as yet been able to pinpoint what may cause this disease, a new report published in the journal, JAMA Neurology offers up some important clues.

The study evaluated blood samples from 156 individuals with confirmed ALS and compared them to blood samples from 128 similarly aged controls. Blood concentrations of 122 environmental pollutants were studied, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and brominated flame retardants (BFRs), using highly sophisticated techniques including gas chromatography–mass spectrometry. To be sure, these chemicals are directly toxic to the nervous system and are highly persistent in the environment, as well as in the human body

Further, beyond the blood analysis, the researchers also collected data about risk for environmental exposure based on factors such as occupation and known exposure in the past.

The results of the study were telling. The researchers found that the study participants who reported a history of pesticide exposure showed a strong correlation to ALS risk by an incredible 5-foldIn addition, a dramatic relationship was seen in those with higher levels of various toxins in their blood.

The authors concluded:

Our findings identify classes of pollutants that increase the likelihood of ALS and therefore are modifiable disease risk factors.

While the chemical names of the various toxins are compelling, it’s really important to recognize that many of these chemicals continue to be widely used.  So we need to do everything we possibly can to look at our lifestyle and occupational choices through the lens of risk management. For example, I often write about the fundamental importance of choosing organic foods, and the relationship between these toxins and ALS only strengthens my plea.

ALS- See more at: http://www.drperlmutter.com/lifestyle-choices-may-affect-als-risk/?mc_cid=ba2f42100d&mc_eid=f5aef745a5#.ca8aPDZO.dpuf

Association of Environmental Toxins With Amyotrophic Lateral Sclerosis
Publication
JAMA Neurology

Author(s)
Feng-Chiao Su, PhD; Stephen A. Goutman, MD; Sergey Chernyak, PhD; Bhramar Mukherjee, PhD; Brian C. Callaghan, MD; Stuart Batterman, PhD; Eva L. Feldman, MD, PhD

Abstract
Importance: Persistent environmental pollutants may represent a modifiable risk factor involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS).

Objective: To evaluate the association of occupational exposures and environmental toxins on the odds of developing ALS in Michigan.

Design, Setting, and Participants: Case-control study conducted between 2011 and 2014 at a tertiary referral center for ALS. Cases were patients diagnosed as having definitive, probable, probable with laboratory support, or possible ALS by revised El Escorial criteria; controls were excluded if they were diagnosed as having ALS or another neurodegenerative condition or if they had a family history of ALS in a first- or second-degree blood relative. Participants completed a survey assessing occupational and residential exposures. Blood concentrations of 122 persistent environmental pollutants, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and brominated flame retardants (BFRs), were measured using gas chromatography–mass spectrometry. Multivariable models with self- reported occupational exposures in various exposure time windows and environmental toxin blood concentrations were separately fit by logistic regression models. Concordance between the survey data and pollutant measurements was assessed using the nonparametric Kendall τ correlation coefficient.

Main Outcomes and Measures: Occupational and residential exposures to environmental toxins, and blood concentrations of 122 persistent environmental pollutants, including OCPs, PCBs, and BFRs.

Results: Participants included 156 cases (mean

[SD] age, 60.5 [11.1] years; 61.5% male) and 128 controls (mean [SD] age, 60.4 [9.4] years; 57.8% male); among them, 101 cases and 110 controls had complete demographic and pollutant data. Survey data revealed that reported pesticide exposure in the cumulative exposure windows was significantly associated with ALS (odds ratio [OR] = 5.09; 95% CI, 1.85-13.99; P = .002). Military service was also associated with ALS in 2 time windows (exposure ever happened in entire occupational history: OR = 2.31; 95% CI, 1.02-5.25; P = .046; exposure ever happened 10-30 years ago: OR = 2.18; 95% CI, 1.01-4.73; P = .049). A multivariable model of measured persistent environmental pollutants in the blood, representing cumulative occupational and residential exposure, showed increased odds of ALS for 2 OCPs (pentachlorobenzene: OR = 2.21; 95% CI, 1.06-4.60; P = .04; and cis-chlordane: OR = 5.74; 95% CI, 1.80-18.20; P = .005), 2 PCBs (PCB 175: OR = 1.81; 95% CI, 1.20-2.72; P = .005; and PCB 202: OR = 2.11; 95% CI, 1.36-3.27; P = .001), and 1 BFR (polybrominated diphenyl ether 47: OR = 2.69; 95% CI, 1.49-4.85; P = .001). There was modest concordance between survey data and the measurements of persistent environmental pollutants in blood; significant Kendall τ correlation coefficients ranged from −0.18 (Dacthal and “use pesticides to treat home or yard”) to 0.24 (trans-nonachlor and “store lawn care products in garage”).

Conclusions and Relevance: In this study, persistent environmental pollutants measured in blood were significantly associated with ALS and may represent modifiable ALS disease risk factors.

Date
May 9, 2016

 

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Dr. Kadish is an unusual physician often referred to as a "doctor detective". His expertise is the evaluation and treatment of complex disorders, typically after other physicians have been stumped, is renowned. He provides care for all family members and has additional training in autistic spectrum disorders and chronic complex diseases.